Anti-SS-A antibodies and fetal outcome in maternal systemic lupus erythematosus

Arthritis Rheum. 1986 Oct;29(10):1269-73. doi: 10.1002/art.1780291013.


In 155 women with systemic lupus erythematosus, there were no significant differences in the rates of fertility or adverse fetal outcome between the 47 (30%) with serum anti-SS-A antibody and the 108 without anti-SS-A, except in the frequency of congenital heart block. This complication occurred in 6 of 96 pregnancies in women with anti-SS-A and was associated with high-titer maternal antibody. The overall risk of a woman with lupus having an infant with congenital heart block was estimated to be 1:60, but the risk was considerably higher (1:20) if anti-SS-A antibody was present.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abortion, Spontaneous / etiology
  • Antibodies, Antinuclear / analysis*
  • Female
  • Fetal Death
  • Heart Block / congenital
  • Humans
  • Infant, Newborn
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / immunology
  • Obstetric Labor, Premature / etiology
  • Pregnancy
  • Pregnancy Complications / immunology*
  • Retrospective Studies
  • Risk


  • Antibodies, Antinuclear
  • SS-A antibodies