NCCN Guidelines® Insights: Squamous Cell Skin Cancer, Version 1.2022

J Natl Compr Canc Netw. 2021 Dec;19(12):1382-1394. doi: 10.6004/jnccn.2021.0059.


The NCCN Guidelines for Squamous Cell Skin Cancer provide recommendations for diagnostic workup, clinical stage, and treatment options for patients with cutaneous squamous cell carcinoma. The NCCN panel meets annually to discuss updates to the guidelines based on comments from panel members and the Institutional Review, as well as submissions from within NCCN and external organizations. These NCCN Guidelines Insights focus on the introduction of a new surgical recommendation terminology (peripheral and deep en face margin assessment), as well as recent updates on topical prophylaxis, immunotherapy for regional and metastatic disease, and radiation therapy.

MeSH terms

  • Carcinoma, Squamous Cell* / diagnosis
  • Carcinoma, Squamous Cell* / therapy
  • Epithelial Cells
  • Humans
  • Immunotherapy
  • Skin Neoplasms* / diagnosis
  • Skin Neoplasms* / therapy