Corticotropin-releasing factor mRNA in the hypothalamus is affected differently by drinking saline and by dehydration

FEBS Lett. 1986 Nov 10;208(1):158-62. doi: 10.1016/0014-5793(86)81553-8.


Corticotropin-releasing factor (CRF) stimulates the synthesis and release of adrenocorticotropin in the anterior pituitary and may help maintain fluid and electrolyte balance. 'Salt-loaded' rats had an increase in CRF mRNA in hypothalamic magnocellular neurons of the paraventricular and supraoptic nuclei and a decrease in message in the parvocellular paraventricular neurons. After salt-loaded rats were adrenalectomized, CRF mRNA increased in the parvocellular cells. In contrast to salt loading, water deprivation lead to a decrease in CRF mRNA in magnocellular and parvocellular neurons. These results show that CRF synthesis within separate populations of hypothalamic neurons is regulated differently under various conditions.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenalectomy
  • Animals
  • Corticotropin-Releasing Hormone / genetics*
  • Dehydration / metabolism
  • Hypothalamus / metabolism*
  • Male
  • Paraventricular Hypothalamic Nucleus / metabolism
  • RNA, Messenger / metabolism*
  • Rats
  • Rats, Inbred Strains
  • Sodium Chloride / pharmacology
  • Water-Electrolyte Balance*


  • RNA, Messenger
  • Sodium Chloride
  • Corticotropin-Releasing Hormone