Myoepithelioma-like tumour of the vulval region: A case report

Australas J Dermatol. 2022 Feb;63(1):e52-e55. doi: 10.1111/ajd.13761. Epub 2021 Dec 14.


Myoepithelioma-like tumours of the vulvar region (MELTVR) are a newly described group of spindle cell neoplasm. Morphologically, they consist of epithelioid to spindled cells in a myxoid to collagenous stroma and can resemble epithelioid sarcomas, myoepithelial carcinomas or extraskeletal myxoid chondrosarcomas. However, they have a distinct pattern of immunohistochemical staining characterised by positivity for EMA, ER, PR and negativity for cytokeratin, GFAP and S100. Nuclear staining for INI-1 is lost. In addition, they lack the characteristic gene arrangements of these other lesions. MELTVR can recur locally when incompletely excised, however, do not appear to metastasize. We report a case of a MELTVR in a 49-year-old woman arising in the right mons pubis.

Keywords: Myoepithelioma; benign; neoplasm; tumour; vulva.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Humans
  • Middle Aged
  • Myoepithelioma / pathology*
  • Myoepithelioma / surgery
  • Vulvar Neoplasms / pathology*
  • Vulvar Neoplasms / surgery