Loss of ciliary activity in organ cultures of rat trachea treated with lipo-oligosaccharide from Haemophilus influenzae

J Med Microbiol. 1986 Nov;22(3):265-8. doi: 10.1099/00222615-22-3-265.

Abstract

Organ culture of rat trachea was used as an experimental model to examine the ability of lipo-oligosaccharide from Haemophilus influenzae to damage respiratory tract mucosal tissue. Lipo-oligosaccharide from two strains of H. influenzae produced a significant decrease in the ciliary activity of tracheal rings observed over a 3-5 day period. No loss of ciliary activity was observed with the lipid-free moiety of the lipo-oligosaccharide.

MeSH terms

  • Animals
  • Cilia / drug effects
  • Endotoxins / pharmacology*
  • Female
  • Haemophilus influenzae*
  • Lipopolysaccharides / pharmacology*
  • Male
  • Organ Culture Techniques
  • Rats
  • Rats, Inbred Lew
  • Rats, Inbred Strains
  • Trachea / drug effects*
  • Trachea / ultrastructure

Substances

  • Endotoxins
  • Lipopolysaccharides
  • lipid-linked oligosaccharides