Serotonergic Regulation of Hepatic Energy Metabolism

Endocrinol Metab (Seoul). 2021 Dec;36(6):1151-1160. doi: 10.3803/EnM.2021.1331. Epub 2021 Dec 16.

Abstract

The liver is a vital organ that regulates systemic energy metabolism and many physiological functions. Nonalcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease and end-stage liver failure. NAFLD is primarily caused by metabolic disruption of lipid and glucose homeostasis. Serotonin (5-hydroxytryptamine [5-HT]) is a biogenic amine with several functions in both the central and peripheral systems. 5-HT functions as a neurotransmitter in the brain and a hormone in peripheral tissues to regulate systemic energy homeostasis. Several recent studies have proposed various roles of 5-HT in hepatic metabolism and inflammation using tissue-specific knockout mice and 5-HT-receptor agonists/antagonists. This review compiles the most recent research on the relationship between 5-HT and hepatic metabolism, and the role of 5-HT signaling as a potential therapeutic target in NAFLD.

Keywords: Liver; Non-alcoholic fatty liver disease; Serotonin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Energy Metabolism
  • Homeostasis
  • Mice
  • Non-alcoholic Fatty Liver Disease* / metabolism
  • Serotonin

Substances

  • Serotonin