Orbital Histoplasmosis Due to Histoplasma Capsulatum Var. Duboisii: Successful Treatment With Septrin

J Trop Med Hyg. 1986 Aug;89(4):179-87.


Four children with orbital histoplasmosis caused by Histoplasma capsulatum var. duboisii (one of whom had been unsuccessfully treated with amphotericin-B) were treated with a combination of trimethoprim and sulphamethoxazole (Septrin) and surgical drainage. All patients improved markedly during therapy with resolution of the lesions, and with no recurrence of infection in three patients, 1 year later. The fourth patient was lost to follow-up. Treatment was devoid of side effects. These findings clearly indicate that Septrin could be a safe alternative to amphotericin-B for the treatment of African histoplasmosis, especially in patients presenting with solitary or localized lesions.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anti-Infective Agents / therapeutic use*
  • Child
  • Drainage
  • Drug Combinations / therapeutic use
  • Female
  • Histoplasmosis / diagnosis
  • Histoplasmosis / drug therapy*
  • Histoplasmosis / surgery
  • Humans
  • Male
  • Orbital Diseases / diagnosis
  • Orbital Diseases / drug therapy*
  • Orbital Diseases / surgery
  • Sulfamethoxazole / therapeutic use*
  • Trimethoprim / therapeutic use*
  • Trimethoprim, Sulfamethoxazole Drug Combination


  • Anti-Infective Agents
  • Drug Combinations
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Trimethoprim
  • Sulfamethoxazole