Effects of rubidium chloride on the course of manic-depressive illness

J R Soc Med. 1978 May;71(5):343-52.


Clinical studies of the effects of rubidium ions on the course of manic-depressive illness are reported. It seems that rubidium tends to increase the length of manic phases and possibly reduces the extremes of mood. Rubidium did not seem to produce any severe side effects in the dose administered, but it has a long biological half-life and caution is still required. Some details of the CSF, RBC, saliva and plasma and urine kinetics are also reported.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Affect / drug effects
  • Aged
  • Bipolar Disorder / drug therapy*
  • Bipolar Disorder / metabolism
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Half-Life
  • Humans
  • Male
  • Middle Aged
  • Motor Activity / drug effects
  • Rubidium / metabolism
  • Rubidium / therapeutic use*
  • Speech / drug effects


  • Rubidium