Role of immunohistochemistry markers in neoplastic lung lesions

J Cancer Res Ther. 2021 Oct-Dec;17(6):1382-1388. doi: 10.4103/jcrt.JCRT_187_19.

Abstract

Objectives: The objective of the evaluate was to study and determine the usefulness of immunohistochemistry (IHC) staining in neoplastic lung lesions.

Materials and methods: We evaluated seven IHC stains in fifty lung cancers that included adenocarcinoma (AC), squamous cell carcinoma (SCC), small cell carcinoma, and carcinoid tumors.

Results: P63 was expressed in all the cases of SCCs and thyroid transcription factor-1 (TTF-1) was expressed in all cases of ACs. CK 5/6 was expressed in 77.77% of SCCs and CK 7 was expressed in 92.59% of ACs. Synaptophysin and chromogranin-A were expressed in 100% of neuroendocrine (NE) carcinomas.

Conclusion: P63 and TTF-1 are sensitive markers for SCCs and ACs. Synaptophysin and Chromogranin-A are sensitive markers for NE carcinomas.

Keywords: Adenocarcinoma; immunohistochemistry; lung.

MeSH terms

  • Adenocarcinoma of Lung / diagnosis*
  • Adenocarcinoma of Lung / metabolism
  • Biomarkers, Tumor / metabolism*
  • Carcinoma, Non-Small-Cell Lung / diagnosis*
  • Carcinoma, Non-Small-Cell Lung / metabolism
  • Carcinoma, Squamous Cell / diagnosis*
  • Carcinoma, Squamous Cell / metabolism
  • Diagnosis, Differential
  • Humans
  • Immunohistochemistry / methods*
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / metabolism
  • Prognosis
  • Small Cell Lung Carcinoma / diagnosis*
  • Small Cell Lung Carcinoma / metabolism

Substances

  • Biomarkers, Tumor