The analgetic efficacy of a new non-steroidal anti-inflammatory drug fluproquazone (RF 46-790, Sandoz A. G., Switzerland) was tested versus paracetamol in a double-blind parallel group study using pain after surgical removal of impacted third molars. The patients received 3 doses of 100 mg fluproquazone or 500 mg paracetamol. Statistical analysis was made for the first and last dose. No statistically significant difference was found between the two treatment groups with respect to the first and last dose taken. Only minor complaints of side effects were noted with no statistically significant difference between the two groups. The study indicates equianalgesia of 100 mg fluproquazone and 500 mg paracetamol which is supported by studies with other pain models. The analgetic properties of fluproquazone are reviewed.