Central sensitisation in primary Sjögren Syndrome and its effect on sleep quality

Mod Rheumatol. 2022 Aug 20;32(5):908-914. doi: 10.1093/mr/roab075.


Objective: The aim of the present study is to evaluate the presence and frequency of central sensitisation (CS) in primary Sjögren Syndrome (pSS) and to determine the effect of CS on sleep quality.

Materials and methods: In this cross-sectional study, 50 patients diagnosed with pSS between the ages of 18 and 75 were included. The healthy control group was composed of 43 healthcare workers. Each participant underwent a physical examination, and demographic data and the medications they used were recorded. Central sensitisation inventory and Pittsburgh Sleep Quality Index questionnaires were filled in to garner data on CS and sleep quality, respectively, from all participants.

Results: While central sensitisation inventory >40 was detected in 74% of pSS patients, it was 25.6% in healthy controls, and there is a statistically significant difference between the groups (p < .05). A correlation analysis of the central sensitisation inventory and Pittsburgh Sleep Quality Index values of all participants revealed a statistically significant correlation between all parameters other than the duration of sleep (p < .05).

Conclusions: CS was found to have a negative effect on sleep quality in patients with pSS. We suggest that the cause of widespread pain seen in patients with pSS as the possible development of CS should be considered.

Keywords: Central sensitisation; pain; primary Sjögren Syndrome; sleep quality.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Central Nervous System Sensitization*
  • Cross-Sectional Studies
  • Humans
  • Middle Aged
  • Sjogren's Syndrome* / complications
  • Sleep Quality
  • Surveys and Questionnaires
  • Young Adult