HLA-DR4 as a predictor of outcome three years after onset of rheumatoid arthritis

Rheumatol Int. 1986;6(5):233-5. doi: 10.1007/BF00541373.


Data from 59 patients with early rheumatoid arthritis were analysed to determine the predictive value of the possession of HLA-DR4 for disease severity and functional outcome at 3 years after disease onset. The previously reported association of that antigen with seropositive disease was confirmed. Conversely, however, there was no evidence that functional outcome was worse in the HLA-DR4 positive group as measured by the Stanford Health Assessment Questionnaire. The mean articular index was lower in the HLA-DR4 group which also had a smaller proportion with limited wrist extension. In addition, both patient and physicians' global assessment of disease status were better in the HLA-DR4 group. It is concluded that HLA-DR4 is not a useful predictor of poor outcome at 3 years.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / diagnosis*
  • Arthritis, Rheumatoid / genetics
  • Female
  • HLA-D Antigens / analysis*
  • HLA-DR Antigens / analysis*
  • HLA-DR4 Antigen
  • Humans
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prognosis


  • HLA-D Antigens
  • HLA-DR Antigens
  • HLA-DR4 Antigen