Streptooctatins A and B, fusicoccane-type diterpenoids with autophagic activity from Streptomyces sp. KCB17JA11

Bioorg Med Chem Lett. 2022 Feb 1;57:128504. doi: 10.1016/j.bmcl.2021.128504. Epub 2021 Dec 15.

Abstract

Two new fusicoccane-type diterpenoids, streptooctatins A (1) and B (2), together with a known compound cyclooctatin (3) were isolated from Streptomyces sp. KCB17JA11. The structures of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and HRESIMS experiments. Compounds 1 and 2 induced EGFP-LC3 puncta indicating autophagic activities against HeLa cells without cytotoxicity.

Keywords: Autophagy; Fusicoccane-type diterpenoids; Secondary metabolites; Streptomyces sp..