Streptooctatins A and B, fusicoccane-type diterpenoids with autophagic activity from Streptomyces sp. KCB17JA11

Jun-Pil Jang; Mina Jang; Gwi Ja Hwang; Min Hee Kim; Jong Seog Ahn; Sung-Kyun Ko; Jae-Hyuk Jang

doi:10.1016/j.bmcl.2021.128504

Streptooctatins A and B, fusicoccane-type diterpenoids with autophagic activity from Streptomyces sp. KCB17JA11

Bioorg Med Chem Lett. 2022 Feb 1:57:128504. doi: 10.1016/j.bmcl.2021.128504. Epub 2021 Dec 15.

Authors

Jun-Pil Jang¹, Mina Jang¹, Gwi Ja Hwang², Min Hee Kim¹, Jong Seog Ahn³, Sung-Kyun Ko⁴, Jae-Hyuk Jang⁵

Affiliations

¹ Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, South Korea.
² Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, South Korea; Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, South Korea.
³ Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, South Korea; Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, South Korea. Electronic address: jsahn@kribb.re.kr.
⁴ Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, South Korea; Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, South Korea. Electronic address: ksk1230@kribb.re.kr.
⁵ Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, South Korea; Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, South Korea. Electronic address: jangjh@kribb.re.kr.

PMID: 34922027
DOI: 10.1016/j.bmcl.2021.128504

Abstract

Two new fusicoccane-type diterpenoids, streptooctatins A (1) and B (2), together with a known compound cyclooctatin (3) were isolated from Streptomyces sp. KCB17JA11. The structures of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and HRESIMS experiments. Compounds 1 and 2 induced EGFP-LC3 puncta indicating autophagic activities against HeLa cells without cytotoxicity.

Keywords: Autophagy; Fusicoccane-type diterpenoids; Secondary metabolites; Streptomyces sp..

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autophagy / drug effects*
Diterpenes / chemistry
Diterpenes / isolation & purification
Diterpenes / pharmacology*
HeLa Cells
Humans
Microtubule-Associated Proteins / metabolism
Molecular Structure
Stereoisomerism
Streptomyces / chemistry*

Substances

Diterpenes
MAP1LC3A protein, human
Microtubule-Associated Proteins