Long-term Outcomes of Cataract Surgery in Patients with Retinitis Pigmentosa

Ophthalmol Retina. 2022 Apr;6(4):268-272. doi: 10.1016/j.oret.2021.12.010. Epub 2021 Dec 16.


Purpose: To investigate the long-term outcomes of cataract surgery in patients with retinitis pigmentosa (RP).

Design: Retrospective, observational study.

Participants: Sixty-four patients with typical RP (22 men, 42 women; average age, 62.8 ± 10.1 years) who underwent cataract surgery at Kyushu University Hospital between May 2007 and October 2015 and were followed up for ≥3 years after the surgery.

Methods: Differences between presurgery and postsurgery visual function, including best-corrected visual acuity (BCVA) and parameters in the Humphrey field analyzer (HFA) examination using the central 10-2 program, were investigated. The presurgery conditions of the foveal ellipsoid zone (EZ) were classified into 3 grades (grade 1: invisible; grade 2: abnormal; grade 3: normal) based on OCT findings.

Main outcome measures: BCVA, the retinal sensitivity in the HFA 10-2 test.

Results: Cataract surgery was performed in 96 eyes, with an average follow-up period of 5.8 ± 2.4 years. The mean presurgery BCVA was 0.64 ± 0.52 logarithm of the minimum angle of resolution (logMAR), and the final postsurgery BCVA was 0.61 ± 0.67 logMAR (P = 0.57). Significant improvement in the postsurgery BCVA was observed only in eyes with preserved foveal EZ (grade 3) (P < 0.01). In 62 eyes of 45 patients who underwent the HFA 10-2 test, the mean values of deviation, macular sensitivity, and foveal sensitivity at the final visit were significantly decreased compared with preoperative values (P < 0.01), whereas those in grade 3 eyes did not change significantly after the surgery (P = 0.13).

Conclusions: In the long-term course after cataract surgery in patients with RP, many patients experienced vision loss with progression of the disease. The preoperative finding of preserved foveal EZ was associated with a better visual prognosis, suggesting that EZ evaluation is useful for predicting the long-term visual outcome of cataract surgery in patients with RP.

Keywords: Humphrey field analyzer (HFA); best-corrected visual acuity (BCVA); central 10-2 program; ellipsoid zone (EZ); long term; macular EZ status; presurgery; retinitis pigmentosa; retrospective; visual field.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cataract* / complications
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retinitis Pigmentosa* / complications
  • Retinitis Pigmentosa* / diagnosis
  • Retinitis Pigmentosa* / surgery
  • Retrospective Studies
  • Tomography, Optical Coherence
  • Visual Acuity