Suppression of overt diabetes in NOD mice by anti-thymocyte serum or anti-Thy 1, 2 antibody

Jikken Dobutsu. 1986 Oct;35(4):501-4. doi: 10.1538/expanim1978.35.4_501.

Abstract

Effects of anti-thymocyte serum (ATS) and anti-Thy 1, 2 monoclonal antibody on the spontaneously occurring diabetes in NOD mice were examined. Spontaneous diabetes in female mice was markedly suppressed by intravenous injection of rabbit anti-mouse thymocyte serum diluted to 1:4 on three consecutive days during the time period from 70 to 100 days after birth; the cumulative incidence of overt diabetes upto 195 days of age was greatly reduced and the onset of diabetes was delayed. Similar effect was observed with anti-Thy 1, 2 antibody treatment. These findings suggest that T lymphocytes play a role in the production of spontaneous diabetes in this mouse strain.

MeSH terms

  • Animals
  • Antilymphocyte Serum / immunology*
  • Diabetes Mellitus, Experimental / immunology*
  • Diabetes Mellitus, Type 1 / immunology*
  • Female
  • Immune Tolerance*
  • Isoantibodies / immunology*
  • Mice
  • T-Lymphocytes / immunology

Substances

  • Antilymphocyte Serum
  • Isoantibodies
  • anti-Thy antibody