The Origins of Merkel Cell Carcinoma: Defining Paths to the Neuroendocrine Phenotype

J Invest Dermatol. 2022 Mar;142(3 Pt A):507-509. doi: 10.1016/j.jid.2021.11.011. Epub 2021 Dec 17.


Two recent reports leverage careful genomic analysis to show that human Merkel cell carcinomas (MCCs) arising from squamous cell carcinoma in situ bear hallmarks of genetic relatedness, suggesting that a subset of MCCs can arise from pre-existing intraepithelial keratinocytic proliferations in human skin. This has important implications for our understanding of cells of origin and the diverse drivers of MCC formation.

Publication types

  • Comment

MeSH terms

  • Carcinoma in Situ*
  • Carcinoma, Merkel Cell* / genetics
  • Carcinoma, Merkel Cell* / pathology
  • Carcinoma, Squamous Cell* / genetics
  • Humans
  • Merkel cell polyomavirus*
  • Phenotype
  • Skin Neoplasms* / genetics
  • Skin Neoplasms* / pathology