One stomach, two subtypes of carcinoma-the differences between distal and proximal gastric cancer

Yuan Zhang; Peng-Shan Zhang; Ze-Yin Rong; Chen Huang

doi:10.1093/gastro/goab050

One stomach, two subtypes of carcinoma-the differences between distal and proximal gastric cancer

Gastroenterol Rep (Oxf). 2021 Nov 15;9(6):489-504. doi: 10.1093/gastro/goab050. eCollection 2021 Dec.

Authors

Yuan Zhang¹, Peng-Shan Zhang¹, Ze-Yin Rong¹, Chen Huang¹

Affiliation

¹ Department of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, P. R. China.

Abstract

Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract, posing a significant risk to human health. Over the past 10 years, the pathological characteristics and the prognosis of GC have been determined based on the locations of the tumors that were then classified into two types-proximal and distal GC. This review focuses on the differences in epidemiology, etiology, cell source, pathological characteristics, gene expression, molecular markers, manifestations, treatment, prognosis, and prevention between proximal and distal GC to provide guidance and a basis for clinical diagnosis and treatment.

Keywords: epidemiology; gastric cancer; pathology; prognosis; therapeutics.

Publication types

Review