Odookeanynes A and B, Acetylene-Containing Lipopeptides from an Okeania sp. Marine Cyanobacterium

Aki Yamano; Yuka Asato; Noriyuki Natsume; Arihiro Iwasaki; Kiyotake Suenaga; Toshiaki Teruya

doi:10.1021/acs.jnatprod.1c00915

Odookeanynes A and B, Acetylene-Containing Lipopeptides from an Okeania sp. Marine Cyanobacterium

J Nat Prod. 2022 Jan 28;85(1):169-175. doi: 10.1021/acs.jnatprod.1c00915. Epub 2021 Dec 20.

Authors

Aki Yamano¹, Yuka Asato², Noriyuki Natsume², Arihiro Iwasaki³, Kiyotake Suenaga³, Toshiaki Teruya^{1

2}

Affiliations

¹ Faculty of Education, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
² Graduate School of Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
³ Department of Chemistry, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.

PMID: 34928625
DOI: 10.1021/acs.jnatprod.1c00915

Abstract

Odookeanynes A (1) and B (2), two acetylene-containing lipopeptides, were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa, Japan. Their structures were elucidated by spectroscopic analysis and Marfey's analysis of acid hydrolysates. Odookeanynes A (1) and B (2) dose-dependently promoted the differentiation of mouse 3T3-L1 preadipocytes in the presence of insulin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

3T3-L1 Cells
Acetylene / chemistry*
Adipocytes / cytology
Adipocytes / drug effects
Animals
Cell Differentiation / drug effects
Chromatography, High Pressure Liquid
Cyanobacteria / chemistry*
Dose-Response Relationship, Drug
Insulin / pharmacology
Lipopeptides / chemistry
Lipopeptides / isolation & purification*
Mice
Protein Conformation
Seawater / microbiology*

Substances

Insulin
Lipopeptides
Acetylene