Cruciferous vegetable and isothiocyanate intake and multiple health outcomes

Food Chem. 2022 May 1:375:131816. doi: 10.1016/j.foodchem.2021.131816. Epub 2021 Dec 14.


Isothiocyanates, bioactive phytochemicals of cruciferous vegetables, have chemopreventative efficacy. To clarify evidence of associations between cruciferous vegetable and isothiocyanate intake and various health outcomes, we conducted an umbrella review of meta-analyses and systematic reviews in humans. A total of 413 articles were identified, and 57 articles with 24 health outcomes were included. Consumption of cruciferous vegetables was associated with a reduced risk of all-cause mortality, cancers, and depression. Dose-response analyses revealed that a per 100 g/d increment was associated with a 10% decrease in the risk of all-cause mortality. Warfarin resistance caused by vitamin K-rich broccoli was reported. Caution was warranted for those allergies/hypersensitivities to the Brassica genus. The intake of cruciferous vegetables is generally safe and beneficial in humans. However the quality of the majority (68%) of evidence was low.

Keywords: Cruciferous vegetables; Health; Isothiocyanates; Meta-analysis; Systematic review; Umbrella review.

Publication types

  • Review

MeSH terms

  • Brassica*
  • Diet
  • Humans
  • Isothiocyanates
  • Meta-Analysis as Topic
  • Outcome Assessment, Health Care
  • Systematic Reviews as Topic
  • Vegetables*


  • Isothiocyanates
  • isothiocyanic acid