Centennial Review: A meta-analysis of the significance of Eimeria infection on apparent ileal amino acid digestibility in broiler chickens

Abstract

Eimeria infections impair digestive tract capacity and barrier function leading to poor growth and feed efficiency. A meta-analysis approach was used to evaluate and quantify impact of Eimeria infection on the apparent ileal digestibility (AID) of amino acids (AA) in broiler chickens. A database composed of 6 articles with a total of 21 experiments was built for the effect of challenge type (a mix of Eimeria spp. vs. E. acervulina) and subdatabase of 3 articles with a total of 15 experiments for the effect of E. acervulina dose response. Regression models were fitted with the mixed model procedure in Minitab 19 with fixed effects of challenge, species, and their interactions. For the sub database, the mixed model procedure was used to fit regression models and identify a linear or quadratic response to dose. Challenge decreased AID (P < 0.05) of both dispensable and indispensable AA except for Trp. Specifically, the largest depression was observed for Cys, Thr, Tyr, Ala, and Val with the magnitude of difference of 8.7, 5.4, 5.2, 5.1, and 4.9%, respectively for challenged vs. unchallenged birds. The type of challenge affected (P < 0.05) AID of AA with exception of Cys, Tyr, Ala, Ser, Leu, Asp, Gly, and Pro. E. acervulina challenge had larger negative effects on AID of Ile, Leu, and Val. Moreover, E. acervulina linearly decreased (P < 0.05) AID of all indispensable and dispensable AA except for Trp and quadratically (P < 0.05) decreased AID of all AA except Cys, Met, Arg, and Trp. The largest linear decrease due to E. acervulina dose was seen for AID of Cys, followed by Ala, Val, Thr, and Ile. Although, AID of Trp was not affected by E. acervulina challenge, mixed Eimeria species challenge decreased (P < 0.05) AID of Trp. Overall, the results confirmed that an Eimeria infection negatively impacted AA digestibility/utilization. The ranking of the most affected AA suggested ground for nutritional intervention during subclinical field Eimeria infections or vaccination programs.

Keywords: Eimeria challenge; amino acids digestibility; broiler chickens; meta-analysis.