Epidemiology of insulin-dependent diabetes mellitus in Canterbury, New Zealand

Diabetes Res Clin Pract. Jan-Feb 1987;3(1):21-9. doi: 10.1016/s0168-8227(87)80004-9.

Abstract

A prospective study of incidence and prevalence of insulin-dependent diabetes mellitus in persons under 20 years was conducted over a 4-year period (1 February 1982-1 February 1986) for the Canterbury Hospital Board (total population 342,000) area in New Zealand. A central register for the area was established at the beginning of the study period. Degree of ascertainment was close to 100%. Average annual incidence was 11.7 persons per 100,000 (females: 10.6 per 100,000; males: 12.7 per 100,000) with no significant sex difference or temporal trends. Incidence peaks were seen for both sexes in the pubertal ages (females: 11 years; males: 13 years), with minor peaks occurring for both sexes in the pre-school ages. Age of onset was significantly younger in females than males. A seasonal variation in incidence was seen for males, with peaks in late autumn and mid-winter. 5.7% of the new diabetics had a first-degree relative with insulin-dependent diabetes mellitus. Islet cell cytoplasmic antibodies were detected in 68% of new diabetics and in 0% of age- and sex-matched healthy controls. Thyroid, gastric and adrenal auto-antibodies were seen more frequently in diabetics than in controls, but this difference was not significant. Prevalence of insulin-dependent diabetes on 1 February 1982 was 1.00 per 1000 and 1.05 per 1000 on 1 February 1986. The insulin-dependent diabetes mellitus incidence characteristics noted for the Canterbury Hospital Board area are similar to those reported for European and North American populations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Age Factors
  • Autoantibodies / immunology
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 1 / epidemiology*
  • Diabetes Mellitus, Type 1 / genetics
  • Diabetes Mellitus, Type 1 / immunology
  • Female
  • Humans
  • Infant
  • Male
  • New Zealand
  • Organ Specificity
  • Pancreas / cytology
  • Pancreas / immunology
  • Prospective Studies
  • Seasons
  • Sex Factors

Substances

  • Autoantibodies