Abstract
Mice simultaneously expressing the mutations nude and X-linked immune deficiency (xid) were previously shown to have pro-B cells and/or early pre-B cells while lacking C mu+ and surface Ig+ cells. We now report that thymus grafts restore both T cells and B cells in nude-xid mice. By the use of Thy-1 and Igh allogeneic donors it was shown that both the T and B cells were host derived. The B cells had a functional phenotype typical of xid mice. It is concluded that the maturation of xid B cells past the pro-B or early pre-B stage is T cell dependent.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibody Formation
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Antigens / immunology
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B-Lymphocytes / immunology
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B-Lymphocytes / pathology*
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Immunoglobulin Allotypes / analysis
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Immunologic Deficiency Syndromes / genetics
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Immunologic Deficiency Syndromes / immunology*
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Lymphocyte Activation / drug effects
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Lymphocyte Cooperation*
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Mice
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Mice, Inbred AKR
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Mice, Inbred CBA
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Mice, Mutant Strains / genetics
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Mice, Mutant Strains / immunology*
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Mice, Nude / genetics
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Mice, Nude / immunology*
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Mitogens / pharmacology
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Thymus Gland / physiology
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Thymus Gland / transplantation*
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X Chromosome
Substances
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Antigens
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Immunoglobulin Allotypes
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Mitogens