Stressed-out yeast do not pass GO

Hilary A Coller

doi:10.1083/jcb.202111032

Stressed-out yeast do not pass GO

J Cell Biol. 2022 Jan 3;221(1):e202111032. doi: 10.1083/jcb.202111032. Epub 2021 Dec 21.

Author

Hilary A Coller^{1

2

3}

Affiliations

¹ Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA.
² Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
³ Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA.

Abstract

Using microfluidics and imaging, Argüello-Miranda et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202103171) monitor the response of individual yeast cells to nutrient withdrawal. They discover that cells arrest not only in the early G1 phase as expected, but also later in the cell cycle, and that an endoplasmic reticulum stress-induced transcription factor, Xbp1, is critical for arrest at other cell cycle phases.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Cycle
Cell Division
Endoplasmic Reticulum Stress*
Saccharomyces cerevisiae* / genetics

Abstract

Publication types

MeSH terms

Grants and funding