Herpes zoster ophthalmicus with cerebral angiitis and reduced cerebral blood flow

Acta Neurol Scand. 1986 Dec;74(6):460-6. doi: 10.1111/j.1600-0404.1986.tb07871.x.


Two patients with herpes zoster ophthalmicus (HZO) who experienced a delayed contralateral hemiparesis, the so-called crossed zoster syndrome, are described. Particular emphasis is paid to the cerebral blood flow (CBF) findings studied with the Xenon-133 inhalation technique using single photon emission computed tomography (SPECT). In a 40-year-old female with right-sided hemiparesis, angiography showed multiple segmental narrowings of the intracerebral arteries. Cerebral computer tomography (CT) scans were normal. The CBF studied 11 months after the HZO showed a generalized reduction of flow which, however, was more pronounced in the left hemisphere. On re-examination 8 months later both the mean hemispheric flow and regional CBF (rCBF) had increased to normal values. In a 66-year-old male with dysphasia and right-sided hemiparesis, cerebral CT scans demonstrated two small deep left-sided infarcts. CBF examination showed a generalized reduction of flow in the left hemisphere. The flow was slightly increased on re-examination 12 months later. These findings suggest that the Xenon-133 inhalation method represents a useful way to demonstrate the CBF pattern in this group of patients.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Arteritis / etiology
  • Arteritis / physiopathology*
  • Brain / pathology
  • Cerebral Angiography
  • Cerebral Arterial Diseases / etiology
  • Cerebral Arterial Diseases / physiopathology*
  • Cerebral Infarction / pathology
  • Cerebrovascular Circulation*
  • Female
  • Herpes Zoster Ophthalmicus / complications
  • Herpes Zoster Ophthalmicus / physiopathology*
  • Humans
  • Male
  • Tomography, Emission-Computed
  • Tomography, X-Ray Computed
  • Xenon Radioisotopes


  • Xenon Radioisotopes