Objective: To compare the clinical effect of acupuncture combined with wheat-grain moxibustion and oral sertraline hydrochloride dispersible tablets in the treatment of mild to moderate postpartum depression.
Methods: Sixty patients with mild to moderate postpartum depression were randomly divided into an observation group and a control group, 30 cases in each group. Both groups were treated with psychotherapy. The control group was treated with oral sertraline hydrochloride dispersible tablets, 50 mg each time, once a day; the observation group was treated with acupuncture at Qihai (CV 6), Zusanli (ST 36), Xuehai (SP 10), Hegu (LI 4), Sanyinjiao (SP 6), Taixi (KI 3), etc. combined with wheat-grain moxibustion at Xinshu (BL 15), Pishu (BL 20), Ganshu (BL 18) and Shenshu (BL 23), once every other day, 3 times a week. Both groups were treated for 4 weeks as a course, with 2 consecutive courses of treatment. Before and after treatment and follow-up of 3 months after the end of treatment, the Hamilton depression scale (HAMD), Edinburgh postnatal depression scale (EPDS) and World Health Organization quality of life-BREF (WHOQOL-BREF) score of the two groups were compared, and the clinical effect was assessed.
Results: After treatment and during follow-up, the HAMD and EPDS scores of the two groups were lower than before treatment (P<0.05), and the WHOQOL-BREF scores of the two groups were higher than before treatment (P<0.05). In the control group, the scores of HAMD and EPDS during follow-up were higher than after treatment (P<0.05), and the score of WHOQOL-BREF during follow-up was lower than after treatment (P<0.05). After treatment and during follow-up, the HAMD and EPDS scores of the observation group were lower than those of the control group (P<0.05), and the WHOQOL-BREF score of the observation group was higher than that of the control group (P<0.05). The total effective rate of the observation group was 93.3% (28/30), which was higher than 86.7% (26/30) of the control group (P<0.05).
Conclusion: Acupuncture combined with wheat-grain moxibustion can improve the depressive symptoms of patients with mild to moderate postpartum depression and improve their quality of life, and the clinical effect is more lasting and stable than oral sertraline hydrochloride dispersible tablets.
目的：比较针刺结合麦粒灸与口服盐酸舍曲林分散片治疗轻中度产后抑郁症的临床疗效。方法：将60例轻中度产后抑郁症患者随机分为观察组和对照组，每组30例。两组均予心理疗法，对照组予口服盐酸舍曲林分散片治疗，每次50 mg，每日1次；观察组予针刺结合麦粒灸治疗，针刺穴取气海、足三里、血海、合谷、三阴交、太溪等，麦粒灸穴取心俞、脾俞、肝俞、肾俞，均隔日1次，每周3次。两组均治疗4周为一疗程，连续治疗2个疗程。分别于治疗前后及治疗结束后3个月随访时观察两组患者汉密尔顿抑郁量表（HAMD）、爱丁堡产后抑郁量表（EPDS）和世界卫生组织生存质量测定简表（WHOQOL-BREF）评分，并评定临床疗效。结果：两组患者治疗后及随访时HAMD、EPDS评分均较治疗前降低（P<0.05），WHOQOL-BREF评分均较治疗前升高（P<0.05）；对照组患者随访时HAMD、EPDS评分较治疗后升高（P<0.05），WHOQOL-BREF评分较治疗后降低（P<0.05）。观察组患者治疗后及随访时HAMD、EPDS评分均低于对照组（P<0.05），WHOQOL-BREF评分均高于对照组（P<0.05）。观察组总有效率为93.3%（28/30），高于对照组的86.7%（26/30，P<0.05）。结论：针刺结合麦粒灸可改善轻中度产后抑郁症患者抑郁症状，提高其生活质量，临床疗效较口服盐酸舍曲林分散片更持久、稳定。.
Keywords: acupuncture; postpartum depression; quality of life; wheat-grain moxibustion.