Although medication-induced esophagitis is recognized more frequently nowadays, reports of associated radiographic findings are limited. Nine cases of esophagitis associated with various medications were evaluated by using double-contrast esophagography. The usual features were several discrete focal ulcerations localized to a short segment of the proximal half of the esophagus. In seven of the cases, the offending medication was an antibiotic. Symptoms resolved in about 4 days after medication was discontinued. Finding characteristic radiologic abnormalities in the appropriate clinical setting may obviate endoscopy.