A census of the lung: CellCards from LungMAP

Dev Cell. 2022 Jan 10;57(1):112-145.e2. doi: 10.1016/j.devcel.2021.11.007. Epub 2021 Dec 21.


The human lung plays vital roles in respiration, host defense, and basic physiology. Recent technological advancements such as single-cell RNA sequencing and genetic lineage tracing have revealed novel cell types and enriched functional properties of existing cell types in lung. The time has come to take a new census. Initiated by members of the NHLBI-funded LungMAP Consortium and aided by experts in the lung biology community, we synthesized current data into a comprehensive and practical cellular census of the lung. Identities of cell types in the normal lung are captured in individual cell cards with delineation of function, markers, developmental lineages, heterogeneity, regenerative potential, disease links, and key experimental tools. This publication will serve as the starting point of a live, up-to-date guide for lung research at https://www.lungmap.net/cell-cards/. We hope that Lung CellCards will promote the community-wide effort to establish, maintain, and restore respiratory health.

Keywords: COVID; CellCards; LungMAP; cell cards; disease; lung; regeneration; repair; resource; single cell.

Publication types

  • Dataset
  • Research Support, N.I.H., Extramural

MeSH terms

  • Cell Differentiation / genetics
  • Databases as Topic
  • Humans
  • Lung / cytology*
  • Lung / metabolism
  • Lung / physiology*
  • Regeneration / genetics
  • Single-Cell Analysis / methods