Phase Ib dose-escalation study of the selective, non-covalent, reversible Bruton's tyrosine kinase inhibitor vecabrutinib in B-cell malignancies
Haematologica
.
2022 Apr 1;107(4):984-987.
doi: 10.3324/haematol.2021.280061.
Authors
John N Allan
1
,
Javier Pinilla-Ibarz
2
,
Douglas E Gladstone
3
,
Krish Patel
4
,
Jeff P Sharman
5
,
William G Wierda
6
,
Michael Y Choi
7
,
Susan M O'Brien
8
,
Mazyar Shadman
9
,
Matthew S Davids
10
,
John M Pagel
4
,
Habte A Yimer
11
,
Renee Ward
12
,
Gary Acton
12
,
Pietro Taverna
12
,
Daniel L Combs
13
,
Judith A Fox
12
,
Richard R Furman
1
,
Jennifer R Brown
14
Affiliations
1
Weill Cornell Medicine, Department of Medicine, New York.
2
Moffitt Cancer Center, Tampa, FL.
3
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD.
4
Swedish Cancer Institute, Seattle, WA.
5
Willamette Valley Cancer Institute/US Oncology, Eugene, OR.
6
MD Anderson Cancer Center, Houston, TX.
7
Moores Cancer Center, University of California San Diego, La Jolla, CA.
8
Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, CA.
9
Fred Hutchinson Cancer Research Center, Seattle, WA.
10
CLL Center, Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
11
Texas Oncology/US Oncology Research, Tyler, TX.
12
Sunesis Pharmaceuticals, South San Francisco, CA.
13
Combs Consulting Service, Mountain View, CA.
14
CLL Center, Medical Oncology, Dana-Farber Cancer Institute, Boston, MA. jennifer_brown@dfci.harvard.edu.
PMID:
34937320
PMCID:
PMC8968902
DOI:
10.3324/haematol.2021.280061
No abstract available
Publication types
Clinical Trial, Phase I
MeSH terms
Humans
Neoplasms* / drug therapy
Protein Kinase Inhibitors* / administration & dosage
Substances
Protein Kinase Inhibitors