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Review
. 2021 Dec 13:2021:9720618.
doi: 10.1155/2021/9720618. eCollection 2021.

The Association with Subclinical Thyroid Dysfunction and Uric Acid

Yuling Xing  1   2 , Linlin Yang  3 , Jing Liu  1 , Huijuan Ma  1   4
Affiliations
Review

The Association with Subclinical Thyroid Dysfunction and Uric Acid

Yuling Xing et al. Int J Endocrinol. .

Abstract

The relationship between subclinical thyroid dysfunction and uric acid was not well established. This study aimed to determine if subclinical thyroid dysfunction is associated with hyperuricemia risk and to evaluate the levels of uric acid in patients with different forms of subclinical thyroid dysfunction. A systematic search was conducted in 4 databases to obtain relevant studies on subclinical thyroid dysfunction (subclinical hyperthyroidism and subclinical hypothyroidism) and uric acid. The standardized mean difference (SMD) or odds ratio (OR) and 95% confidence interval (95% CI) were used for evaluation, and the sensitivity analysis was conducted. Publication bias was estimated by funnel plot, Egger's test, and Begg's test. A total of 73 studies were included in this meta-analysis. The results demonstrated that serum levels of uric acid in patients with subclinical hypothyroidism were significantly higher than those of controls and patients with subclinical hyperthyroidism. Patients with subclinical thyroid dysfunction had a higher prevalence of hyperuricemia compared with normal clinical thyroid function. Subclinical thyroid dysfunction was associated with the prevalence of hyperuricemia. Different types of subclinical thyroid dysfunction had varied effects on serum levels of uric acid.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Literature screening process and results.
Figure 2
Figure 2
(a) Forest plot of subclinical thyroid dysfunction and hyperuricemia. (b) Forest plot of the comparison of subclinical hypothyroidism and subclinical hyperthyroidism. (c) Funnel plot of subclinical thyroid dysfunction and hyperuricemia. (d) Funnel plot of the comparison of subclinical hypothyroidism and subclinical hyperthyroidism.
Figure 3
Figure 3
(a) Forest plot of subclinical hypothyroidism and uric acid. (b) Subgroup analysis of subclinical hypothyroidism, grouped by area. (c) Subgroup analysis of subclinical hypothyroidism, grouped by age. (d) Subgroup analysis of subclinical hypothyroidism, grouped by basic diseases. (e) Funnel plot of subclinical hypothyroidism.
Figure 4
Figure 4
(a) Forest plot of subclinical hyperthyroidism and uric acid. (b) Subgroup analysis of subclinical hyperthyroidism, grouped by area. (c) Subgroup analysis of subclinical hyperthyroidism, grouped by age. (d) Subgroup analysis of subclinical hyperthyroidism, grouped by basic diseases. (e) Funnel plot of subclinical hyperthyroidism.
Figure 5
Figure 5
Relationship between SCH and serum UA levels before and after treatment. (a) Forest plot. (b) Funnel plot.
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