Therapy-related myeloid neoplasms resembling juvenile myelomonocytic leukemia: a case series and review of the literature

Pediatr Blood Cancer. 2022 May;69(5):e29499. doi: 10.1002/pbc.29499. Epub 2021 Dec 22.


Therapy-related myeloid neoplasms (t-MN) are a distinct subgroup of myeloid malignancies with a poor prognosis that include cases of therapy-related myelodysplastic syndrome (t-MDS), therapy-related myeloproliferative neoplasms (t-MPN) and therapy-related acute myeloid leukemia (t-AML). Here, we report a series of patients with clinical features consistent with juvenile myelomonocytic leukemia (JMML), an overlap syndrome of MDS and myeloproliferative neoplasms that developed after treatment for another malignancy.

Keywords: AML; JMML; MDS; secondary; therapy related.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Leukemia, Myelomonocytic, Juvenile* / diagnosis
  • Leukemia, Myelomonocytic, Juvenile* / therapy
  • Myelodysplastic Syndromes* / chemically induced
  • Myelodysplastic Syndromes* / diagnosis
  • Myelodysplastic Syndromes* / therapy
  • Myeloproliferative Disorders*
  • Neoplasms, Second Primary* / diagnosis