An Investigation of ABO Blood Type and the Platelet Delta Granule Storage Pool

Clin Appl Thromb Hemost. 2021 Jan-Dec:27:10760296211068818. doi: 10.1177/10760296211068818.


Individuals with bleeding tendencies are more likely to have blood type O than blood types A, B, or AB. Platelet storage pool deficiencies are a lesser-known group of bleeding disorders which often go undiagnosed and may account for a significant number of patients with unexplained bleeding defects. We hypothesized that patients with platelet δ-storage pool deficiency might also have a predominance of type O blood. A retrospective review of medical records of 2,020 patients with unexplained bleeding and evaluated for δ-storage pool deficiency was performed. Correlations between dense granule numbers, blood type, and von Willebrand factor were analyzed for statistical differences. 51.5% of blood samples were blood type O compared to an incidence of 44.0% in the U.S. population. There was a significant association of vWF and blood type O but not with the delta storage pool. There is a preponderance of blood type O in the study population compared to the U.S. population. There is no statistically significant link between blood type O and lower dense granule numbers in this study.

Keywords: ABO; bleeding; blood type; platelets; storage pool deficiency.

MeSH terms

  • ABO Blood-Group System / blood*
  • Adult
  • Bleeding Time
  • Blood Platelets / ultrastructure*
  • Female
  • Humans
  • Male
  • Microscopy, Electron
  • Platelet Aggregation / physiology*
  • Platelet Storage Pool Deficiency / blood*
  • Platelet Storage Pool Deficiency / pathology
  • Retrospective Studies
  • von Willebrand Factor / metabolism*


  • ABO Blood-Group System
  • von Willebrand Factor