Caging NLRP3 tames inflammasome activity

Cell. 2021 Dec 22;184(26):6224-6226. doi: 10.1016/j.cell.2021.11.035.


How the danger sensor NLRP3 is activated is intensively debated. Using cryo-electron microscopy (EM) approaches, Andreeva and colleagues made the remarkable discovery that inactive NLRP3 forms a double ring of 12-16 monomers that shield its pyrin domains from the cytosol. We discuss this surprising new mechanism of inflammasome regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Cryoelectron Microscopy
  • Cytosol
  • Inflammasomes*
  • NLR Family, Pyrin Domain-Containing 3 Protein*


  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein