Pluripotent Stem Cells for Spinal Cord Injury Repair

Cells. 2021 Nov 27;10(12):3334. doi: 10.3390/cells10123334.


Spinal cord injury (SCI) is a devastating condition of the central nervous system that strongly reduces the patient's quality of life and has large financial costs for the healthcare system. Cell therapy has shown considerable therapeutic potential for SCI treatment in different animal models. Although many different cell types have been investigated with the goal of promoting repair and recovery from injury, stem cells appear to be the most promising. Here, we review the experimental approaches that have been carried out with pluripotent stem cells, a cell type that, due to its inherent plasticity, self-renewal, and differentiation potential, represents an attractive source for the development of new cell therapies for SCI. We will focus on several key observations that illustrate the potential of cell therapy for SCI, and we will attempt to draw some conclusions from the studies performed to date.

Keywords: ESC; NSC; PSC; animal models; cell therapy; iPSC; tetraplegia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Clinical Trials as Topic
  • Embryonic Stem Cells / transplantation
  • Humans
  • Induced Pluripotent Stem Cells / transplantation
  • Pluripotent Stem Cells / transplantation*
  • Spinal Cord Injuries / therapy*
  • Spinal Cord Regeneration*