Deodorant Activity of Black Cumin Seed Essential Oil against Garlic Organosulfur Compound

Biomolecules. 2021 Dec 14;11(12):1874. doi: 10.3390/biom11121874.


The deodorant activity of black cumin (Nigella sativa L.) seed, a spice used to flavor curry and vegetable foods in Southwest Asia, against garlic (Allium sativum L.) organosulfur compounds related to human malodor was evaluated. Black cumin seed essential oil showed remarkable deodorant activity against garlic essential oil. The mode of action of this deodorant activity was presumed to be that black cumin seed essential oil covalently reacted with the organosulfur compounds in garlic. Therefore, thymoquinone, which is a major constituent in black cumin seed essential oil, and allyl mercaptan, which is one of the organosulfur compounds produced by cutting garlic, were reacted in vitro, and the products were purified and elucidated using spectroscopic data. As a result, these substances were identified as different allyl mercaptan adducts to dihydrothymoquinone. This chemical reaction was presumed to play a key role in the deodorant activity of black cumin seed essential oil.

Keywords: Nigella sativa L.; black cumin seed essential oil; deodorant activity; garlic organosulfur compounds.

MeSH terms

  • Benzoquinones / chemistry
  • Benzoquinones / pharmacology*
  • Deodorants / pharmacology*
  • Garlic / chemistry*
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Hydrogen-Ion Concentration
  • Nigella sativa / chemistry*
  • Oils, Volatile / chemistry
  • Oils, Volatile / pharmacology
  • Plant Oils / chemistry
  • Plant Oils / pharmacology
  • Seeds / chemistry
  • Sulfhydryl Compounds / chemistry


  • Benzoquinones
  • Deodorants
  • Oils, Volatile
  • Plant Oils
  • Sulfhydryl Compounds
  • thymoquinone