Androgen Receptors in Skeletal Muscle Cytosol From Sheep Treated With Trenbolone Acetate

Horm Metab Res. 1987 Mar;19(3):110-4. doi: 10.1055/s-2007-1011754.


Female sheep were implanted with the anabolic agent trenbolone acetate and the effects of the treatment on the skeletal muscle androgen receptor studied. In two separate trials the binding capacity/mg skeletal muscle protein was reduced. In trial 1 the animals were implanted (80 mg trenbolone acetate) at the start and after 5 weeks of the trial and samples taken one week later while in the second trial samples were taken 15 days after a single implant (80 mg trenbolone acetate). The ability of a variety of steroids and steroid-like compounds to displace [3H] testosterone and [3H] methyltrienolone was also studied. The androgen receptor was also partially purified using heparin-sepharose chromatography The involvement of the anddrogen receptor in the mode of action of trenbolone is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding, Competitive
  • Chromatography
  • Cytosol / metabolism
  • Estrenes / metabolism
  • Estrenes / pharmacology*
  • Female
  • Metribolone
  • Muscles / metabolism*
  • Receptors, Androgen / drug effects
  • Receptors, Androgen / metabolism*
  • Sheep
  • Testosterone / metabolism
  • Trenbolone Acetate / analogs & derivatives
  • Trenbolone Acetate / pharmacology*


  • Estrenes
  • Receptors, Androgen
  • Metribolone
  • Testosterone
  • Trenbolone Acetate