Abstract
We performed an annotation of 35 mutations in the spike protein of the SARS-CoV-2 Omicron variant. Our analysis of the mutations indicates that Omicron has gained prominent immune evasion and potential for enhanced transmissibility. Previous modeling study has revealed that continued evolution in both immune evasion and enhanced transmissibility by SARS-CoV-2 would compromise vaccines as tools for the pandemic control. To combat the future variants of SARS-CoV-2, the world needs novel antiviral drugs that are effective at curb viral spreading without introducing additional selective pressure towards resistant variants.
Keywords:
COVID19; COVID19drugs; COVID19vaccines; Omicron variants; SARS-CoV-2.
MeSH terms
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Angiotensin-Converting Enzyme 2 / genetics
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Angiotensin-Converting Enzyme 2 / immunology
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Angiotensin-Converting Enzyme 2 / metabolism*
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Antiviral Agents / chemical synthesis
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Antiviral Agents / therapeutic use
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Binding Sites
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COVID-19 / epidemiology
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COVID-19 / prevention & control
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COVID-19 / transmission
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COVID-19 Drug Treatment*
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COVID-19 Vaccines / administration & dosage
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COVID-19 Vaccines / adverse effects
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Drug Design / methods*
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Humans
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Immune Evasion
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Mutation
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Protein Binding
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Receptors, Virus / genetics
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Receptors, Virus / immunology
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Receptors, Virus / metabolism*
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SARS-CoV-2 / drug effects
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SARS-CoV-2 / genetics*
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SARS-CoV-2 / immunology
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SARS-CoV-2 / pathogenicity
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Spike Glycoprotein, Coronavirus / genetics*
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Spike Glycoprotein, Coronavirus / immunology
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Spike Glycoprotein, Coronavirus / metabolism
Substances
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Antiviral Agents
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COVID-19 Vaccines
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Receptors, Virus
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Spike Glycoprotein, Coronavirus
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spike protein, SARS-CoV-2
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ACE2 protein, human
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Angiotensin-Converting Enzyme 2