Simultaneous modeling of reaction times and brain dynamics in a spatial cueing task

Hum Brain Mapp. 2022 Apr 15;43(6):1850-1867. doi: 10.1002/hbm.25758. Epub 2021 Dec 24.

Abstract

Understanding how brain activity translates into behavior is a grand challenge in neuroscientific research. Simultaneous computational modeling of both measures offers to address this question. The extension of the dynamic causal modeling (DCM) framework for blood oxygenation level-dependent (BOLD) responses to behavior (bDCM) constitutes such a modeling approach. However, only very few studies have employed and evaluated bDCM, and its application has been restricted to binary behavioral responses, limiting more general statements about its validity. This study used bDCM to model reaction times in a spatial attention task, which involved two separate runs with either horizontal or vertical stimulus configurations. We recorded fMRI data and reaction times (n= 26) and compared bDCM with classical DCM and a behavioral Rescorla-Wagner model using Bayesian model selection and goodness of fit statistics. Results indicate that bDCM performed equally well as classical DCM when modeling BOLD responses and as good as the Rescorla-Wagner model when modeling reaction times. Although our data revealed practical limitations of the current bDCM approach that warrant further investigation, we conclude that bDCM constitutes a promising method for investigating the link between brain activity and behavior.

Keywords: behavioral; dynamic causal modeling; effective connectivity; fMRI; simultaneous modeling; spatial attention.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bayes Theorem
  • Brain Mapping / methods
  • Brain* / diagnostic imaging
  • Brain* / physiology
  • Humans
  • Models, Neurological*
  • Reaction Time