Mammary analogue secretory carcinoma: A challenging case arising in a young man with radiation exposure

Priyadharshini Sivasubramaniam; Christin A Tiegs-Heiden; Katherine B Geiersbach; Catherine E Hagen; Charles D Sturgis; Judith Jebastin Thangaiah; Christopher P Hartley

doi:10.1016/j.anndiagpath.2021.151862

Mammary analogue secretory carcinoma: A challenging case arising in a young man with radiation exposure

Ann Diagn Pathol. 2022 Apr:57:151862. doi: 10.1016/j.anndiagpath.2021.151862. Epub 2021 Nov 22.

Authors

Priyadharshini Sivasubramaniam¹, Christin A Tiegs-Heiden², Katherine B Geiersbach¹, Catherine E Hagen¹, Charles D Sturgis¹, Judith Jebastin Thangaiah¹, Christopher P Hartley³

Affiliations

¹ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
² Department of Radiology, Mayo Clinic, Rochester, MN, USA.
³ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: Hartley.Christopher@mayo.edu.

PMID: 34953444
DOI: 10.1016/j.anndiagpath.2021.151862

Abstract

Mammary Analogue Secretory Carcinoma (MASC) is a recently described salivary gland tumor frequently sampled via fine-needle aspiration. The cytologic features of MASC are not entirely distinctive and can simulate acinic cell carcinoma, but the tumor harbors an ETV6 gene rearrangement resulting in an ETV6-NTRK3 fusion gene. We present a case of MASC arising in a 31 year old man with a history of multiple radio-embolization procedures.

Keywords: Fine-needle aspiration; MASC; Mammary analogue secretory carcinoma; Salivary gland tumors.

Publication types

Case Reports

MeSH terms

Adult
Biomarkers, Tumor / genetics
Humans
Male
Mammary Analogue Secretory Carcinoma* / genetics
Mammary Analogue Secretory Carcinoma* / pathology
Oncogene Proteins, Fusion / genetics
Radiation Exposure*
Salivary Gland Neoplasms* / genetics
Salivary Gland Neoplasms* / pathology

Substances

Biomarkers, Tumor
Oncogene Proteins, Fusion