The tactile sensors of the gut

Sarah A Najjar; Kara Gross Margolis

doi:10.1016/j.tins.2021.12.003

The tactile sensors of the gut

Trends Neurosci. 2022 Mar;45(3):173-175. doi: 10.1016/j.tins.2021.12.003. Epub 2021 Dec 22.

Authors

Sarah A Najjar¹, Kara Gross Margolis²

Affiliations

¹ Department of Pediatrics, Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY, USA.
² Department of Pediatrics, Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY, USA. Electronic address: kjg2133@cumc.columbia.edu.

PMID: 34953615
DOI: 10.1016/j.tins.2021.12.003

Abstract

In a recent study, Treichel, Finholm et al. showed that the mechanoreceptor Piezo2 enables enteroendocrine cells in the intestinal epithelium to sense luminal contents. Through neuroepithelial signaling, these cells modulate intestinal motility and transit of digestive products.

Keywords: GI physiology; Piezo2; enteroendocrine cells; ion channels; mechanosensitivity; neuroepithelial connection.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Enteroendocrine Cells
Humans
Ion Channels*
Mechanoreceptors
Touch*

Substances

Ion Channels

Abstract

Publication types

MeSH terms

Substances

Grants and funding