The inhibitory effect of succinate on radiation-enhanced mitochondrial lipid peroxidation

Int J Radiat Biol Relat Stud Phys Chem Med. 1987 Apr;51(4):611-7. doi: 10.1080/09553008414552141.


The degree of mitochondrial ADP/Fe/NADPH-induced lipid peroxidation was increased up to the fourth day after 9.0 Gy whole body gamma-irradiation. The lipid peroxidation inhibiting effect of succinate added to isolated mitochondria was diminished as a consequence of irradiation. The succinate, administered in vivo prior to irradiation, decreased the amount of malondialdehyde production and protected the succinate dehydrogenase enzyme against inactivation. The mean survival of succinate-pretreated animals was much longer than that of controls. The role of mitochondrial lipid peroxidation in the pathogenesis of radiation injury is discussed.

MeSH terms

  • Adenosine Diphosphate / metabolism
  • Animals
  • Gamma Rays
  • Lipid Peroxides / metabolism*
  • Male
  • Malondialdehyde / biosynthesis
  • Mitochondria, Liver / metabolism*
  • NAD / metabolism
  • Radiation-Protective Agents*
  • Rats
  • Succinate Dehydrogenase / metabolism
  • Succinates / pharmacology*


  • Lipid Peroxides
  • Radiation-Protective Agents
  • Succinates
  • NAD
  • Malondialdehyde
  • Adenosine Diphosphate
  • Succinate Dehydrogenase