Effects of Cannabis in Parkinson's Disease: A Systematic Review and Meta-Analysis

J Parkinsons Dis. 2022;12(2):495-508. doi: 10.3233/JPD-212923.


The legalization of cannabis in many countries has allowed many Parkinson's disease (PD) patients to turn to cannabis as a treatment. As such there is a growing interest from the PD community to be properly guided by evidence regarding potential treatment benefits of cannabis. This systematic review and meta-analysis aims to compile the best available evidence to help guide patients and their family, clinicians and researchers make informed decisions. A systematic search of the literature was conducted in June 2021. Five randomized controlled studies and eighteen non-randomized studies investigated cannabis treatment in PD patients. No compelling evidence was found to recommend the use of cannabis in PD patients. However, a potential benefit was identified with respect to alleviation of PD related tremor, anxiety, pain, improvement of sleep quality and quality of life. Given the relative paucity of well-designed randomized studies, there is an identified need for further investigation, particularly in these areas.

Keywords: Cannabis; Parkinson’s disease; UPDRS; efficacy of cannabis; tremor.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Analgesics
  • Cannabis*
  • Humans
  • Medical Marijuana* / therapeutic use
  • Parkinson Disease* / drug therapy
  • Quality of Life
  • Tremor


  • Analgesics
  • Medical Marijuana