Hadrontherapy techniques for breast cancer

Crit Rev Oncol Hematol. 2022 Jan;169:103574. doi: 10.1016/j.critrevonc.2021.103574. Epub 2021 Dec 24.


Radiotherapy plays a key role in breast cancer treatment, and recent technical advances have been made to improve the therapeutic window by limiting the risk of radiation-induced toxicity or by increasing tumor control. Hadrontherapy is a form a radiotherapy relying on particle beams; compared with photon beams, particle beams have specific physical, radiobiological and immunological properties, which can be valuable in diverse clinical situations. To date, available hadrontherapy techniques for breast cancer irradiation include proton therapy, carbon ion radiation therapy, fast neutron therapy and boron neutron capture therapy. This review analyzes the current rationale and level of evidence for each hadrontherapy technique for breast cancer.

Keywords: Boron neutron capture therapy; Breast cancer; Carbon ion radiation therapy; Fast neutron therapy; Proton therapy.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms* / radiotherapy
  • Female
  • Heavy Ion Radiotherapy*
  • Humans
  • Proton Therapy*