Effect of Vitamin E Supplement on Bone Turnover Markers in Postmenopausal Osteopenic Women: A Double-Blind, Randomized, Placebo-Controlled Trial

Nutrients. 2021 Nov 25;13(12):4226. doi: 10.3390/nu13124226.


Vitamin E is a strong anti-oxidative stress agent that affects the bone remodeling process. This study evaluates the effect of mixed-tocopherol supplements on bone remodeling in postmenopausal osteopenic women. A double-blinded, randomized, placebo-controlled trial study was designed to measure the effect of mixed-tocopherol on the bone turnover marker after 12 weeks of supplementation. All 52 osteopenic postmenopausal women were enrolled and allocated into two groups. The intervention group received mixed-tocopherol 400 IU/day, while the control group received placebo tablets. Fifty-two participants completed 12 weeks of follow-up. Under an intention-to-treat analysis, vitamin E produced a significant difference in the mean bone resorption marker (serum C-terminal telopeptide of type I collagen (CTX)) compared with the placebo group (-0.003 ± 0.09 and 0.121 ± 0.15, respectively (p < 0.001)). In the placebo group, the CTX had increased by 35.3% at 12 weeks of supplementation versus baseline (p < 0.001), while, in the vitamin E group, there was no significant change of bone resorption marker (p < 0.898). In conclusion, vitamin E (mixed-tocopherol) supplementation in postmenopausal osteopenic women may have a preventive effect on bone loss through anti-resorptive activity.

Keywords: bone health; bone marker turnover; bone turnover; osteopenia; postmenopausal women; tocopherol; vitamin E.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Biomarkers
  • Bone Diseases, Metabolic / blood
  • Bone Diseases, Metabolic / complications
  • Bone Diseases, Metabolic / therapy*
  • Bone Remodeling / drug effects*
  • Bone Resorption / blood
  • Bone Resorption / therapy
  • Collagen Type I / blood
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Humans
  • Intention to Treat Analysis
  • Middle Aged
  • Osteoporosis, Postmenopausal / etiology
  • Osteoporosis, Postmenopausal / prevention & control
  • Peptides / blood
  • Postmenopause / blood
  • Postmenopause / drug effects*
  • Treatment Outcome
  • Vitamin E / administration & dosage*


  • Biomarkers
  • Collagen Type I
  • Peptides
  • collagen type I trimeric cross-linked peptide
  • Vitamin E