Beneficial Properties of Bromelain

Nutrients. 2021 Nov 29;13(12):4313. doi: 10.3390/nu13124313.


Bromelain is a major sulfhydryl proteolytic enzyme found in pineapple plants, having multiple activities in many areas of medicine. Due to its low toxicity, high efficiency, high availability, and relative simplicity of acquisition, it is the object of inexhaustible interest of scientists. This review summarizes scientific reports concerning the possible application of bromelain in treating cardiovascular diseases, blood coagulation and fibrinolysis disorders, infectious diseases, inflammation-associated diseases, and many types of cancer. However, for the proper application of such multi-action activities of bromelain, further exploration of the mechanism of its action is needed. It is supposed that the anti-viral, anti-inflammatory, cardioprotective and anti-coagulatory activity of bromelain may become a complementary therapy for COVID-19 and post-COVID-19 patients. During the irrepressible spread of novel variants of the SARS-CoV-2 virus, such beneficial properties of this biomolecule might help prevent escalation and the progression of the COVID-19 disease.

Keywords: COVID-19 disease; SARS-CoV-2 virus; bromelain; cancer; cardiovascular diseases; coagulation; fibrinolysis; inflammation.

Publication types

  • Review

MeSH terms

  • Ananas / enzymology
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / therapeutic use*
  • Anticoagulants / chemistry
  • Anticoagulants / therapeutic use*
  • Blood Coagulation Disorders / drug therapy*
  • Bromelains / chemistry
  • Bromelains / therapeutic use*
  • COVID-19 Drug Treatment*
  • Cardiotonic Agents / chemistry
  • Cardiotonic Agents / therapeutic use*
  • Cardiovascular Diseases / drug therapy*
  • Fibrinolysis / drug effects
  • Humans
  • Neoplasms / drug therapy*
  • Plant Proteins / chemistry
  • Plant Proteins / therapeutic use*
  • SARS-CoV-2*


  • Anti-Inflammatory Agents
  • Anticoagulants
  • Cardiotonic Agents
  • Plant Proteins
  • Bromelains