Immunopathology of RSV: An Updated Review

Viruses. 2021 Dec 10;13(12):2478. doi: 10.3390/v13122478.

Abstract

RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding of virus-host interactions and immunity contribute to the lack of biological countermeasures. This review updates the current understanding of RSV immunity and immunopathology with a focus on interferon responses, animal modeling, and correlates of protection.

Keywords: RSV; host–pathogen interaction; immunity; immunopathology; respiratory syncytial virus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity
  • Animals
  • Disease Models, Animal
  • Humans
  • Immunity, Innate
  • Interferons / immunology
  • Interferons / metabolism
  • Respiratory Syncytial Virus Infections / epidemiology
  • Respiratory Syncytial Virus Infections / immunology*
  • Respiratory Syncytial Virus Infections / prevention & control
  • Respiratory Syncytial Virus Infections / virology*
  • Respiratory Syncytial Virus Vaccines / immunology
  • Respiratory Syncytial Virus, Human / immunology*
  • Respiratory Syncytial Virus, Human / physiology

Substances

  • Respiratory Syncytial Virus Vaccines
  • Interferons