T lymphocyte subpopulations in chronic lymphocytic leukemia of B cell type in relation to immunoglobulin isotype(s) on the leukemic clone and to clinical features

Eur J Haematol. 1987 Mar;38(3):261-7. doi: 10.1111/j.1600-0609.1987.tb01174.x.


Total blood T lymphocytes and subpopulations (OKT4+ and OKT8+ cells) were studied in 59 patients with B cell chronic lymphocytic leukemia (B-CLL). In 48 previously untreated patients, total T lymphocytes were higher as compared to healthy controls (p less than 0.001). T-cells and OKT8+ cells were significantly increased in patients in advanced clinical stage and with progressive disease in comparison to patients with low stage and indolent disease. High numbers of OKT8+ lymphocytes were also seen in patients with a dominance of mu heavy chains on the leukemic clone. Moreover, in this patient group the OKT8+ subpopulation correlated with total B cells (r = 0.68, p less than 0.001) while in patients with a mu delta phenotype no such correlation was seen. After successful cytostatic therapy there was a reduction in total numbers of both OKT4+ and OKT8+ cells, in particular, with a concomitant increase in OKT4/OKT8 ratios.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents / therapeutic use
  • B-Lymphocytes
  • Clone Cells
  • Female
  • Humans
  • Immunoglobulin Isotypes / metabolism*
  • Leukemia, Lymphoid / drug therapy
  • Leukemia, Lymphoid / metabolism
  • Leukemia, Lymphoid / pathology*
  • Leukocyte Count
  • Male
  • Middle Aged
  • Neoplasm Staging
  • T-Lymphocytes / classification*


  • Antineoplastic Agents
  • Immunoglobulin Isotypes