An adaptive PPG (Photoplethysmography) readout system for a dual-channel OLED-OPD flexible sensor is designed and developed with motion artifact (<1Hz) and ambient lighting interference successfully compensated without any additional motion sensors. The compensation is made possible by adopting multi-feedbacks and an additional reference OPD channel to cancel effectively DC drifts. In result, the quality of measured PPG is improved to the level such that long-time, continuous quality monitoring of bio-sign such as heart rate (HR) is possible. The readout is designed with an auto-programmable band-pass trans-impedance amplifier (TIA) of a 100dbΩ gain with a continuous-type DC-current cancellation loop. The rest of the readout consists of a 0.5 Hz low-pass filter, an additional second-order band-pass filter (0.1-10Hz), a difference amplifier, a motion reference channel, an analog multiplexer, a programmable gain amplifier (PGA), a digital control and a programmable DAC-PWM based auto-intensity tuned OLED driver. The readout is fabricated in an area of 9 mm2 via the TSMC 180nm process. The experiment result shows that the developed OLED-OPD readout senses well as small as 1nA current, with a measured dynamic range >90dB (1nA to 100 µA) and input-referred noise of 0.26 nA/√H, with power consumption of 460µW. The DC drift is successfully reduced to 1% of its average. The accuracy for heart rate is 96%.