Ultrasonographic Assessment of Diaphragmatic Inspiratory Amplitude and Its Association with Postoperative Pulmonary Complications in Upper Abdominal Surgery: A Prospective, Longitudinal, Observational Study

Prasanna V Vanamail; Kalpana Balakrishnan; Sarojini Prahlad; Punitha Chockalingam; Radhika Dash; Dinesh K Soundararajan

doi:10.5005/jp-journals-10071-23962

Ultrasonographic Assessment of Diaphragmatic Inspiratory Amplitude and Its Association with Postoperative Pulmonary Complications in Upper Abdominal Surgery: A Prospective, Longitudinal, Observational Study

Indian J Crit Care Med. 2021 Sep;25(9):1031-1039. doi: 10.5005/jp-journals-10071-23962.

Authors

Prasanna V Vanamail¹, Kalpana Balakrishnan², Sarojini Prahlad³, Punitha Chockalingam¹, Radhika Dash¹, Dinesh K Soundararajan¹

Affiliations

¹ Department of Anaesthesiology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.
² Department of Anaesthesiology, Pain and Palliative Care, Cancer Institute (WIA), Chennai, Tamil Nadu, India.
³ Department of Radiology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.

Abstract

Background: Diaphragmatic dysfunction following upper abdominal surgery is less recognized due to a lack of diagnostic modality for bedside evaluation. We used point-of-care ultrasound to evaluate the diaphragmatic inspiratory amplitude (DIA) in upper abdominal surgery for cancer. Our primary hypothesis was DIA would be reduced in the immediate postoperative period in patients with postoperative pulmonary complications (PPCs). Our aim was to identify an optimal cutoff of DIA for the diagnosis of PPCs.

Methods: We conducted a prospective, observational study in patients aged 18-75 years undergoing elective, upper abdominal oncological surgeries under combined general and epidural anesthesia. Ultrasound evaluation of the diaphragm was done by measuring the DIA in the right and left hemidiaphragms during quiet and deep breathing on the day before surgery and postoperative days (PODs) 1, 2, and 3. Patients were followed up for PPCs until POD 7. The linear mixed-effects model examined the association between DIA and PPCs and other perioperative factors. Receiver-operating characteristics analysis was done to determine the optimal cutoff of DIA in diagnosing PPCs.

Results: DIA measured in the 162 patients showed a significant decrease in their absolute values postoperatively from its preoperative baseline measurement. This decrease in DIA was significantly associated with PPC [right hemidiaphragm, β = -0.17, 95% confidence interval (CI) -0.31 to -0.02, p = 0.001 during quiet breathing; left hemidiaphragm, β = -0.24, 95% CI = -0.44 to -0.04, p = 0.018 and β = -0.40, 95% CI = -0.71 to -0.09, p = 0.012 during quiet and deep breathing, respectively]. A cutoff value of DIA of left hemidiaphragm at 1.3 cm during quiet breathing and 1.6 cm during deep breathing had a sensitivity of 77 and 75%, respectively, in their ability to diagnose PPCs [left hemidiaphragm quiet breathing, area under the curve (AUC): 0.653, 95% CI 0.539-0.768, p = 0.015; left hemidiaphragm deep breathing, AUC: 0.675, 95% CI 0.577-0.773, p = 0.007].

Conclusion: Following upper abdominal surgery, the DIA is decreased and associated with PPCs. DIA of left hemidiaphragm less than 1.3 cm during quiet breathing and 1.6 cm during deep breathing has a sensitivity of 77 and 75%, respectively, in diagnosing PPCs following upper abdominal surgery.

How to cite this article: Vanamail PV, Balakrishnan K, Prahlad S, Chockalingam P, Dash R, Soundararajan DK. Ultrasonographic Assessment of Diaphragmatic Inspiratory Amplitude and Its Association with Postoperative Pulmonary Complications in Upper Abdominal Surgery: A Prospective, Longitudinal, Observational Study. Indian J Crit Care Med 2021;25(9):1031-1039.

Keywords: Diaphragm excursion; Diaphragmatic dysfunction; Diaphragmatic inspiratory amplitude; Gastrectomy; Pancreaticoduodenectomy; Pneumonia; Postoperative; Pulmonary complications; Ultrasound; Upper abdominal surgery.