Characterization of the Morphological Nature of Hollow Spray Dried Dispersion Particles Using X-ray Submicron-Computed Tomography

AAPS PharmSciTech. 2021 Dec 28;23(1):40. doi: 10.1208/s12249-021-02184-7.

¹ Materials Science & Engineering, Bristol Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK. john.gamble@bms.com.
² Materials Science & Engineering, Bristol Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK.
³ DigiM Solution LLC, Burlington, Massachusetts, 01803, USA.
⁴ CEITEC - Central European Institute of Technology, Brno University of Technology, Purkynova 656/123, 612 00, Brno, Czech Republic.
⁵ Institute of Physics, Academy of Sciences of the Czech Republic v.v.i., Na Slovance 1999/2, 182 21, Praha 8, Czech Republic.

Abstract

Graphical Abstract.

Keywords: materials science; morphology; physical characterization; solid dispersion; spray drying.